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This article is an orphan, as few or no other articles link to it. Please introduce links to this page from related articles; suggestions are available. (February 2009) edit Ras suppressor protein 1 Identifiers Symbols RSU1; FLJ31034; RSP-1 External IDs OMIM: 179555 MGI: 103040 HomoloGene: 7521 GeneCards: RSU1 Gene Gene Ontology Molecular function • protein binding Biological process • signal transduction • Ras protein signal transduction Sources: Amigo / EGO RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 6251 20163 Ensembl ENSG00000148484 ENSMUSG00000026727 UniProt Q15404 Q9CSE4 RefSeq (mRNA) NM_012425 NM_009105 RefSeq (protein) NP_036557 NP_033131 Location (UCSC) Chr 10: 16.67 - 16.9 Mb Chr 2: 12.99 - 13.19 Mb PubMed search [1] [2] Ras suppressor protein 1 is a protein that in humans is encoded by the RSU1 gene.[1][2] This gene encodes a protein that is involved in the Ras signal transduction pathway, growth inhibition, and nerve-growth factor induced differentiation processes, as determined in mouse and human cell line studies. In mouse, the encoded protein was initially isolated based on its ability to inhibit v-Ras transformation. Multiple alternatively spliced transcript variants for this gene have been reported; one of these variants was found only in glioma tumors.[2] References ^ Tsuda T, Cutler ML (Feb 1994). "Human RSU1 is highly homologous to mouse Rsu-1 and localizes to human chromosome 10". Genomics 18 (2): 461–2. doi:10.1006/geno.1993.1503. PMID 8288261.  ^ a b "Entrez Gene: RSU1 Ras suppressor protein 1". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6251.  Further reading Cutler ML, Bassin RH, Zanoni L, Talbot N (1992). "Isolation of rsp-1, a novel cDNA capable of suppressing v-Ras transformation.". Mol. Cell. Biol. 12 (9): 3750–6. PMID 1508180.  Tsuda T, Marinetti MR, Masuelli L, Cutler ML (1995). "The Ras suppressor RSU-1 localizes to 10p13 and its expression in the U251 glioblastoma cell line correlates with a decrease in growth rate and tumorigenic potential.". Oncogene 11 (2): 397–403. PMID 7624154.  Matoba R, Okubo K, Hori N, et al. (1994). "The addition of 5'-coding information to a 3'-directed cDNA library improves analysis of gene expression.". Gene 146 (2): 199–207. doi:10.1016/0378-1119(94)90293-3. PMID 8076819.  Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.  Masuelli L, Cutler ML (1996). "Increased expression of the Ras suppressor Rsu-1 enhances Erk-2 activation and inhibits Jun kinase activation.". Mol. Cell. Biol. 16 (10): 5466–76. PMID 8816460.  Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.  Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  Chunduru S, Kawami H, Gullick R, et al. (2003). "Identification of an alternatively spliced RNA for the Ras suppressor RSU-1 in human gliomas.". J. Neurooncol. 60 (3): 201–11. doi:10.1023/A:1021130620178. PMID 12510772.  Gevaert K, Goethals M, Martens L, et al. (2004). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.". Nat. Biotechnol. 21 (5): 566–9. doi:10.1038/nbt810. PMID 12665801.  Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.  Aboulaich N, Vainonen JP, Strålfors P, Vener AV (2005). "Vectorial proteomics reveal targeting, phosphorylation and specific fragmentation of polymerase I and transcript release factor (PTRF) at the surface of caveolae in human adipocytes.". Biochem. J. 383 (Pt 2): 237–48. doi:10.1042/BJ20040647. PMID 15242332.  Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.  Dougherty GW, Chopp T, Qi SM, Cutler ML (2005). "The Ras suppressor Rsu-1 binds to the LIM 5 domain of the adaptor protein PINCH1 and participates in adhesion-related functions.". Exp. Cell Res. 306 (1): 168–79. doi:10.1016/j.yexcr.2005.01.025. PMID 15878342.  Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry.". Mol. Syst. Biol. 3: 89. doi:10.1038/msb4100134. PMID 17353931.  This article on a gene on chromosome 10 is a stub. You can help Wikipedia by expanding it. v • d • e