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(February 2009) edit Cell division cycle 40 homolog (S. cerevisiae) Identifiers Symbols CDC40; EHB3; FLJ10564; MGC102802; PRP17; PRPF17 External IDs OMIM: 605585 MGI: 1918963 HomoloGene: 5716 GeneCards: CDC40 Gene Gene Ontology Cellular component • nucleus • spliceosome Biological process • mRNA processing • RNA splicing • cell division Sources: Amigo / EGO RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 51362 71713 Ensembl ENSG00000168438 ENSMUSG00000038446 UniProt O60508 Q3UXN9 RefSeq (mRNA) NM_015891 XM_483893 RefSeq (protein) NP_056975 XP_483893 Location (UCSC) Chr 6: 110.61 - 110.68 Mb Chr 10: 40.52 - 40.57 Mb PubMed search [1] [2] Pre-mRNA-processing factor 17 is a protein that in humans is encoded by the CDC40 gene.[1][2][3] Pre-mRNA splicing occurs in two sequential transesterification steps. The protein encoded by this gene is found to be essential for the catalytic step II in pre-mRNA splicing process. It is found in the spliceosome, and contains seven WD repeats, which function in protein-protein interactions. This protein has a sequence similarity to yeast Prp17 protein, which functions in two different cellular processes: pre-mRNA splicing and cell cycle progression. It suggests that this protein may play a role in cell cycle progression.[3] References ^ Ben Yehuda S, Dix I, Russell CS, Levy S, Beggs JD, Kupiec M (Oct 1998). "Identification and functional analysis of hPRP17, the human homologue of the PRP17/CDC40 yeast gene involved in splicing and cell cycle control". RNA 4 (10): 1304–12. doi:10.1017/S1355838298980712. PMID 9769104.  ^ Lindsey LA, Garcia-Blanco MA (Jan 1999). "Functional conservation of the human homolog of the yeast pre-mRNA splicing factor Prp17p". J Biol Chem 273 (49): 32771–5. doi:10.1074/jbc.273.49.32771. PMID 9830021.  ^ a b "Entrez Gene: CDC40 cell division cycle 40 homolog (S. cerevisiae)". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=51362.  Further reading Wong WT, Schumacher C, Salcini AE, et al. (1995). "A protein-binding domain, EH, identified in the receptor tyrosine kinase substrate Eps15 and conserved in evolution.". Proc. Natl. Acad. Sci. U.S.A. 92 (21): 9530–4. doi:10.1073/pnas.92.21.9530. PMID 7568168.  Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.  Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.  Salcini AE, Confalonieri S, Doria M, et al. (1997). "Binding specificity and in vivo targets of the EH domain, a novel protein-protein interaction module.". Genes Dev. 11 (17): 2239–49. doi:10.1101/gad.11.17.2239. PMID 9303539.  Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.  Zhou Z, Reed R (1998). "Human homologs of yeast prp16 and prp17 reveal conservation of the mechanism for catalytic step II of pre-mRNA splicing.". EMBO J. 17 (7): 2095–106. doi:10.1093/emboj/17.7.2095. PMID 9524131.  Ben-Yehuda S, Dix I, Russell CS, et al. (2001). "Genetic and physical interactions between factors involved in both cell cycle progression and pre-mRNA splicing in Saccharomyces cerevisiae.". Genetics 156 (4): 1503–17. PMID 11102353.  Jurica MS, Licklider LJ, Gygi SR, et al. (2002). "Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis.". RNA 8 (4): 426–39. doi:10.1017/S1355838202021088. PMID 11991638.  Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6.". Nature 425 (6960): 805–11. doi:10.1038/nature02055. PMID 14574404.  Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.  Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.  Barrios-Rodiles M, Brown KR, Ozdamar B, et al. (2005). "High-throughput mapping of a dynamic signaling network in mammalian cells.". Science 307 (5715): 1621–5. doi:10.1126/science.1105776. PMID 15761153.  Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.  This article on a gene on chromosome 6 is a stub. You can help Wikipedia by expanding it. v • d • e