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edit Nucleoporin 153kDa PDB rendering based on 2gqe. Available structures PDB 2gqe Identifiers Symbols NUP153; HNUP153; N153 External IDs OMIM: 603948 MGI: 2385621 HomoloGene: 68442 GeneCards: NUP153 Gene Gene Ontology Molecular function • DNA binding • transporter activity • protein binding • zinc ion binding • metal ion binding Cellular component • intracellular • nucleus • nuclear pore Biological process • transport Sources: Amigo / EGO RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 9972 218210 Ensembl ENSG00000124789 ENSMUSG00000021374 UniProt P49790 n/a RefSeq (mRNA) NM_005124 NM_175749 RefSeq (protein) NP_005115 NP_786925 Location (UCSC) Chr 6: 17.72 - 17.81 Mb Chr 13: 46.69 - 46.74 Mb PubMed search [1] [2] NUP153, is a human gene that codes for the 153 kDa protein Nucleoporin 153kDa. Nuclear pore complexes are extremely elaborate structures that mediate the regulated movement of macromolecules between the nucleus and cytoplasm. These complexes are composed of at least 100 different polypeptide subunits, many of which belong to the nucleoporin family. Nucleoporins are pore complex-specific glycoproteins characterized by cytoplasmically oriented O-linked N-acetylglucosamine residues and numerous repeats of the pentapeptide sequence XFXFG. The protein encoded by this gene has three distinct domains: a N-terminal region within which a pore targeting domain has been identified, a central region containing multiple zinc finger motifs, and a C-terminal region containing multiple XFXFG repeats.[1] Interactions NUP153 has been shown to interact with SENP2[2][3] and KPNB1.[4][5][6] References ^ "Entrez Gene: NUP153 nucleoporin 153kDa". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9972.  ^ Hang, Jun; Dasso Mary (May. 2002). "Association of the human SUMO-1 protease SENP2 with the nuclear pore". J. Biol. Chem. (United States) 277 (22): 19961–6. doi:10.1074/jbc.M201799200. ISSN 0021-9258. PMID 11896061.  ^ Zhang, Hong; Saitoh Hisato, Matunis Michael J (Sep. 2002). "Enzymes of the SUMO modification pathway localize to filaments of the nuclear pore complex". Mol. Cell. Biol. (United States) 22 (18): 6498–508. doi:10.1128/MCB.22.18.6498-6508.2002. ISSN 0270-7306. PMID 12192048.  ^ Nakielny, S; Shaikh S, Burke B, Dreyfuss G (Apr. 1999). "Nup153 is an M9-containing mobile nucleoporin with a novel Ran-binding domain". EMBO J. (ENGLAND) 18 (7): 1982–95. doi:10.1093/emboj/18.7.1982. ISSN 0261-4189. PMID 10202161.  ^ Kehlenbach, R H; Gerace L (Jun. 2000). "Phosphorylation of the nuclear transport machinery down-regulates nuclear protein import in vitro". J. Biol. Chem. (UNITED STATES) 275 (23): 17848–56. doi:10.1074/jbc.M001455200. ISSN 0021-9258. PMID 10749866.  ^ Ben-Efraim, I; Gerace L (Jan. 2001). "Gradient of increasing affinity of importin beta for nucleoporins along the pathway of nuclear import". J. Cell Biol. (United States) 152 (2): 411–7. doi:10.1083/jcb.152.2.411. ISSN 0021-9525. PMID 11266456.  Further reading Moroianu J (2000). "Nuclear import and export pathways.". J. Cell. Biochem. Suppl 32-33: 76–83. doi:10.1002/(SICI)1097-4644(1999)75:32+<76::AID-JCB10>3.0.CO;2-Q. PMID 10629106.  Adam SA (2002). "The nuclear pore complex.". Genome Biol. 2 (9): REVIEWS0007. PMID 11574060.  McMorrow I, Bastos R, Horton H, Burke B (1994). "Sequence analysis of a cDNA encoding a human nuclear pore complex protein, hnup153.". Biochim. Biophys. Acta 1217 (2): 219–23. PMID 8110839.  Yaseen NR, Blobel G (1997). "Cloning and characterization of human karyopherin beta3.". Proc. Natl. Acad. Sci. U.S.A. 94 (9): 4451–6. doi:10.1073/pnas.94.9.4451. PMID 9114010.  Moroianu J, Blobel G, Radu A (1997). "RanGTP-mediated nuclear export of karyopherin alpha involves its interaction with the nucleoporin Nup153.". Proc. Natl. Acad. Sci. U.S.A. 94 (18): 9699–704. doi:10.1073/pnas.94.18.9699. PMID 9275187.  Zolotukhin AS, Felber BK (1999). "Nucleoporins nup98 and nup214 participate in nuclear export of human immunodeficiency virus type 1 Rev.". J. Virol. 73 (1): 120–7. PMID 9847314.  Ullman KS, Shah S, Powers MA, Forbes DJ (1999). "The nucleoporin nup153 plays a critical role in multiple types of nuclear export.". Mol. Biol. Cell 10 (3): 649–64. PMID 10069809.  Nakielny S, Shaikh S, Burke B, Dreyfuss G (1999). "Nup153 is an M9-containing mobile nucleoporin with a novel Ran-binding domain.". EMBO J. 18 (7): 1982–95. doi:10.1093/emboj/18.7.1982. PMID 10202161.  Bachi A, Braun IC, Rodrigues JP, et al. (2000). "The C-terminal domain of TAP interacts with the nuclear pore complex and promotes export of specific CTE-bearing RNA substrates.". RNA 6 (1): 136–58. doi:10.1017/S1355838200991994. PMID 10668806.  Kehlenbach RH, Gerace L (2000). "Phosphorylation of the nuclear transport machinery down-regulates nuclear protein import in vitro.". J. Biol. Chem. 275 (23): 17848–56. doi:10.1074/jbc.M001455200. PMID 10749866.  Kutay U, Hartmann E, Treichel N, et al. (2001). "Identification of two novel RanGTP-binding proteins belonging to the importin beta superfamily.". J. Biol. Chem. 275 (51): 40163–8. doi:10.1074/jbc.M006242200. PMID 11024021.  Herold A, Suyama M, Rodrigues JP, et al. (2000). "TAP (NXF1) belongs to a multigene family of putative RNA export factors with a conserved modular architecture.". Mol. Cell. Biol. 20 (23): 8996–9008. doi:10.1128/MCB.20.23.8996-9008.2000. PMID 11073998.  Hofmann W, Reichart B, Ewald A, et al. (2001). "Cofactor requirements for nuclear export of Rev response element (RRE)- and constitutive transport element (CTE)-containing retroviral RNAs. An unexpected role for actin.". J. Cell Biol. 152 (5): 895–910. doi:10.1083/jcb.152.5.895. PMID 11238447.  Ben-Efraim I, Gerace L (2001). "Gradient of increasing affinity of importin beta for nucleoporins along the pathway of nuclear import.". J. Cell Biol. 152 (2): 411–7. doi:10.1083/jcb.152.2.411. PMID 11266456.  Dimaano C, Ball JR, Prunuske AJ, Ullman KS (2002). "RNA association defines a functionally conserved domain in the nuclear pore protein Nup153.". J. Biol. Chem. 276 (48): 45349–57. doi:10.1074/jbc.M102592200. PMID 11567018.  Walther TC, Fornerod M, Pickersgill H, et al. (2001). "The nucleoporin Nup153 is required for nuclear pore basket formation, nuclear pore complex anchoring and import of a subset of nuclear proteins.". EMBO J. 20 (20): 5703–14. doi:10.1093/emboj/20.20.5703. PMID 11598013.  Brownawell AM, Macara IG (2002). "Exportin-5, a novel karyopherin, mediates nuclear export of double-stranded RNA binding proteins.". J. Cell Biol. 156 (1): 53–64. doi:10.1083/jcb.200110082. PMID 11777942.  Hang J, Dasso M (2002). "Association of the human SUMO-1 protease SENP2 with the nuclear pore.". J. Biol. Chem. 277 (22): 19961–6. doi:10.1074/jbc.M201799200. PMID 11896061.  v • d • e PDB Gallery 2gqe: Molecular characterization of the Ran binding zinc finger domain   v • d • e Antigens: Autoantigens Dehydrogenase Branched-chain alpha-keto acid dehydrogenase complex · Oxoglutarate dehydrogenase · Pyruvate dehydrogenase Transglutaminase Epidermal transglutaminase · Tissue transglutaminase Nucleoporins NUP35 · NUP37 · NUP43 · NUP50 · NUP54 · NUP62 · NUP85 · NUP88 · NUP93 · NUP98 · NUP107 · NUP133 · NUP153 · NUP155 · NUP160 · NUP188 · NUP210 · NUP205 · NUP214 Other Acetylcholine receptor · Actin · Apolipoprotein H · Cardiolipin · Centromere · Filaggrin(Citrullinate) · Gangliosides · Sp100 nuclear antigen · Thrombin · Topoisomerase M: LMC cell/phys/auag/auab imdf/ipig/hyps/tumr proc, drug(L3/4) This article on a gene on chromosome 6 is a stub. You can help Wikipedia by expanding it. v • d • e